A simplified and efficient extracellular vesicles-based proteomics strategy for early diagnosis of colorectal cancer

ABSTRACT: In this work, we have developed a simplified, fast and efficient EVs-based proteomics strategy to enable biomarker discovery for early diagnosis of CRC. By covalent conjugation of an EV-targeting probe, DSPE, to agarose beads, we achieved one-step enrichment of EVs from plasma fluids in 10 minutes without requirement of expensive equipment and reagents, demonstrating its potential and compatibility in clinical applications.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chu Wang  

PROVIDER: PXD054231 | iProX | Thu Jul 25 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX