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Pan-cancer and multi-omics analyses reveal the diagnostic and prognostic value of BAZ2B

ABSTRACT: The BAZ2B gene belongs to the bromodomain gene family. The proteins encoded by members of this gene family are important components of chromatin remodelling complexes and have a potential role in transcriptional activation. However, the biological significance of BAZ2B in pan-cancer is unknown. In this study, we comprehensively analysed the functional characteristics of BAZ2B in human cancers and its role in immune response using The Cancer Genome Atlas (TCGA), Gene Expression Album (GEO), Genotype-Tissue Expression (GTEx) databases, and tools such as TIMER 2.0 and cBioPortal, and found that BAZ2B is down-regulated in certain cancers, and its overexpression is associated with patients’ poor prognosis, such as bladder, breast and endometrial cancers. In addition, we demonstrated for the first time that BAZ2B was under-expressed in breast cancer cells and promoted proliferation, migration and apoptosis of breast cancer cells.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yan Liu

PROVIDER: PXD054319 | iProX | Fri Jul 26 00:00:00 BST 2024

REPOSITORIES: iProX

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Pan-cancer and multi-omics analyses reveal the diagnostic and prognostic value of BAZ2B

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