Dataset Information
Legionella pneumophila effector LegK3 directly phosphorylates multiple caspases involved in apoptosis signaling, including Caspase-3, Caspase-7, and Caspase-9
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Xiaoyun Liu
PROVIDER: PXD054358 | iProX | Sun Jul 28 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
Phosphorylation of caspases by a bacterial kinase inhibits host programmed cell death.
Nature communications 20240930 1
The intracellular bacterial pathogen Legionella pneumophila utilizes the Dot/Icm system to translocate over 330 effectors into the host cytosol. These virulence factors modify a variety of cell processes, including pathways involved in cell death and survival, to promote bacterial proliferation. Here, we show that the effector LegK3 is a eukaryotic-like Ser/Thr kinase that functions to suppress host apoptosis. Mechanistically, LegK3 directly phosphorylates multiple caspases involved in apoptosis ...[more]
