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Proteome and phosphoproteome of erythrocyte membrane proteins in acute mountain sickness

ABSTRACT: Red blood cells are the most abundant cell type in the human body and are mainly responsible for oxygen transport. Acute altitude sickness is common in people exposed to high altitude environment, which is often accompanied by changes in the number and morphology of red blood cells. However, the relationship between acute mountain sickness and erythrocyte membrane proteome and phosphoproteome is still unclear, which needs to be further explored.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yue Gao

PROVIDER: PXD054572 | iProX | Fri Aug 02 00:00:00 BST 2024

REPOSITORIES: iProX

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Comprehensive Proteomics Profiling Reveals Biomarkers of Oxidative Stress and Membrane Integrity in Red Blood Cells in Acute Altitude Sickness.

Li Shubei S Wang Yihao Y Zhou Wei W Wang Yuguang Y Zhang Zhuo Z Wu Zhenhui Z Tu Bodan B Xiao Chengrong C Liu Defang D Yan Jiao J Ma Zengchun Z Gao Yue Y

ACS omega 20251016 42

Red blood cells (RBCs) are vital for oxygen transport and play a key role in acute mountain sickness (AMS). Phosphorylation is one of the most rapid post-translational modifications in response to environmental changes. However, the relationship between the changes of phosphoproteins in the RBC membrane and AMS has not received much attention. We conducted proteomic and phosphoproteomic profiling of RBC (including reticulocytes and mature erythrocytes) membranes from AMS and non-AMS individuals, ...[more]

PMID: 41179217

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