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Proteins interacting with GBP5 and RSV-SH protein

ABSTRACT: HEK293T were transfected with RSV-SH-HA, GBP5-HA or VR1012(empty vector) respectively for 48 h and then harvested. Co-IP assay were performed with HA beads (Roche, catalog no. 11867423001), the elution was analyzed by mass spectrum. Mass spectrum analysis were performed by the national center for protein science (Beijing, CHN).

ORGANISM(S): Homo Sapiens

SUBMITTER: Wenyan Zhang

PROVIDER: PXD054621 | iProX | Tue Aug 06 00:00:00 BST 2024

REPOSITORIES: iProX

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KRT9 is required for GBP5 suppression of human respiratory syncytial virus.

Qu Xinglong X Zhu Ziqi Z Zhou Xinpei X Wu Xuehan X Liu Xin X Sun Xiaoyu X Zhang Jiayue J Du Guanyi G Xue Runyu R Zhang Qianhua Q Zhang Wenyan W Li Zhaolong Z

Journal of virology 20250121 2

Respiratory syncytial virus (RSV) infections continue to plague infants, young children, and older individuals worldwide. Since there is no specific treatment for RSV, characterizing the interactions between RSV and host factors remains crucial for the eventual development of robust therapeutic interventions. In our previous study, guanylate binding protein 5 (GBP5) was shown to promote excessive RSV-small hydrophobic (RSV-SH) protein secretion by microvesicles and inhibited viral replication. I ...[more]

PMID: 39835811

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