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Quantitative proteomics of candidate biomarkers in NSCLC-derived extracellular vesicles using parallel reaction monitoring assay

ABSTRACT: Quantitative proteomics of candidate biomarkers in NSCLC-derived extracellular vesicles using parallel reaction monitoring assay

ORGANISM(S): Homo Sapiens

SUBMITTER: Xian-En Zhang

PROVIDER: PXD054691 | iProX | Wed Aug 07 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX

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Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non-Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning.

Yuan Ye Y Jiang Hai H Xue Rui R Feng Xiao-Jun XJ Liu Bi-Feng BF Li Lian L Peng Bo B Ren Chen-Shuo CS Li Shi-Min SM Li Na N Li Min M Wang Dian-Bing DB Zhang Xian-En XE

Journal of extracellular vesicles 20250501 5

Antigen fingerprint profiling of tumour-derived extracellular vesicles (TDEVs) in the body fluids is a promising strategy for identifying tumour biomarkers. In this study, proteomic and immunological assays reveal significantly higher CD155 levels in plasma extracellular vesicles (EVs) from patients with non-small cell lung cancer (NSCLC) than from healthy individuals. Utilizing CD155 as a bait protein on the EV membrane, CD155+ TDEVs are enriched from NSCLC patient plasma EVs. In the discovery ...[more]

PMID: 40366616

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