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Proteomic profie of S100A9-immunoprecipitation

ABSTRACT: proteomic profie of S100A9-immunoprecipitation in human amnion fibroblasts

ORGANISM(S): Homo Sapiens

SUBMITTER: Wangsheng Wang

PROVIDER: PXD054794 | iProX | Fri Aug 09 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX

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Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De-Repressing LINE1 Via Heterochromatin Erosion at Parturition.

Zhang Fan F Li Meng-Die MD Pan Fan F Lei Wen-Jia WJ Xi Yang Y Ling Li-Jun LJ Myatt Leslie L Sun Kang K Wang Wang-Sheng WS

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20250402 21

Aging of the fetal membranes participates in labor onset. However, the underlying mechanism is poorly understood. Here, we identify that the classical secretory protein S100 calcium-binding protein A9 (S100A9), upon de-phosphorylation at Thr 113, translocates to the nuclei of amnion fibroblasts of the human fetal membranes, where S100A9 causes heterochromatin erosion via segregation of heterochromatin maintenance proteins, resulting in Long Interspersed Nuclear Element-1 (LINE1) de-repression at ...[more]

PMID: 40171783

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