Identification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Xin Chen
PROVIDER: PXD054904 | iProX | Wed Aug 14 00:00:00 GMT+01:00 2024
REPOSITORIES: iProX
Publications
Identification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly.
Lei Zhiwei Z Gu Yu Y Liu Ying Y Liu Hailiang H Lu Xiaohua X Chen Weijie W Zhou Lu L Pan Pan P Chen Zhuohong Z Yue Zhaoyang Z Ruan Jinhui J Zhu Leqing L Li Guangqiang G Xia Xichun X Yu Yang Y Dai Jianfeng J Chen Xin X
Nature communications 20250226 1
Zika virus (ZIKV) is a member of the Flaviviridae family and causes congenital microcephaly and Guillain-Barré syndrome. Currently, there is a lack of approved vaccines or therapies against ZIKV infection. In this study, we profile vRNA‒host protein interactomes at ZIKV stem‒loop B (SLB) and reveal that interleukin enhancer binding factor 3 (ILF3) and DEAH-box helicase 9 (DHX9) form positive regulators of antiviral RNA inference in undifferentiated human neuroblastoma cells and induced pluripote ...[more]
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