ER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Ying Hu
PROVIDER: PXD055020 | iProX | Tue Aug 20 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
ER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs.
Xiang Zhiyuan Z Hou Guixue G Zheng Shanliang S Lu Minqiao M Li Tianyu T Lin Qingyu Q Liu Hao H Wang Xingwen X Guan Tianqi T Wei Yuhan Y Zhang Wenxin W Zhang Yi Y Liu Chaoran C Li Li L Lei Qun-Ying QY Hu Ying Y
Proceedings of the National Academy of Sciences of the United States of America 20240903 37
Proteostasis and genomic integrity are respectively regulated by the endoplasmic reticulum-associated protein degradation (ERAD) and DNA damage repair signaling pathways, with both pathways essential for carcinogenesis and drug resistance. How these signaling pathways coordinate with each other remains unexplored. We found that ER stress specifically induces the DNA-PKcs-regulated nonhomologous end joining (NHEJ) pathway to amend DNA damage and impede cell death. Intriguingly, sustained ER stres ...[more]
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