Proteomics

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GC/MS data for mouse spleen CD4+ T cells


ABSTRACT: For metabolic profiling of mouse CD4+ T cells, stable isotope labeling (SIL) experiments were performed with in vitro-activated T cells using gas chromatography (GC) coupled to mass spectrometry (MS).

ORGANISM(S): Mus Musculus

SUBMITTER: Hui Zhang  

PROVIDER: PXD055328 | iProX | Sat Aug 24 00:00:00 BST 2024

REPOSITORIES: iProX

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Publications

TIGIT deficiency promotes autoreactive CD4<sup>+</sup> T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis.

Lai Yimei Y   Wang Shuang S   Ren Tingting T   Shi Jia J   Qian Yichao Y   Wang Shuyi S   Zhou Mianjing M   Watanabe Ryu R   Li Mengyuan M   Ruan Xinyuan X   Wang Xin X   Zhuang Lili L   Ke Zunfu Z   Yang Niansheng N   Huang Yuefang Y   Zhang Hui H  

Nature communications 20250515 1


Polymyositis (PM) is a systemic autoimmune disease characterized by muscular inflammatory infiltrates and degeneration. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) contributes to immune tolerance by inhibiting T cell-mediated autoimmunity. Here, we show that a reduced expression of TIGIT in CD4<sup>+</sup> T cells from patients with PM promotes these cells' differentiation into Th1 and Th17 cells, which could be rescued by TIGIT overexpression. Knockout of TIGIT enhances muscle inflam  ...[more]

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