Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Hui Zhang
PROVIDER: PXD055328 | iProX | Sat Aug 24 00:00:00 BST 2024
REPOSITORIES: iProX
Lai Yimei Y Wang Shuang S Ren Tingting T Shi Jia J Qian Yichao Y Wang Shuyi S Zhou Mianjing M Watanabe Ryu R Li Mengyuan M Ruan Xinyuan X Wang Xin X Zhuang Lili L Ke Zunfu Z Yang Niansheng N Huang Yuefang Y Zhang Hui H
Nature communications 20250515 1
Polymyositis (PM) is a systemic autoimmune disease characterized by muscular inflammatory infiltrates and degeneration. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) contributes to immune tolerance by inhibiting T cell-mediated autoimmunity. Here, we show that a reduced expression of TIGIT in CD4<sup>+</sup> T cells from patients with PM promotes these cells' differentiation into Th1 and Th17 cells, which could be rescued by TIGIT overexpression. Knockout of TIGIT enhances muscle inflam ...[more]