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GC/MS data for mouse spleen CD4+ T cells

ABSTRACT: For metabolic profiling of mouse CD4+ T cells, stable isotope labeling (SIL) experiments were performed with in vitro-activated T cells using gas chromatography (GC) coupled to mass spectrometry (MS).

ORGANISM(S): Mus Musculus

SUBMITTER: Hui Zhang

PROVIDER: PXD055328 | iProX | Sat Aug 24 00:00:00 BST 2024

REPOSITORIES: iProX

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TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis.

Lai Yimei Y Wang Shuang S Ren Tingting T Shi Jia J Qian Yichao Y Wang Shuyi S Zhou Mianjing M Watanabe Ryu R Li Mengyuan M Ruan Xinyuan X Wang Xin X Zhuang Lili L Ke Zunfu Z Yang Niansheng N Huang Yuefang Y Zhang Hui H

Nature communications 20250515 1

Polymyositis (PM) is a systemic autoimmune disease characterized by muscular inflammatory infiltrates and degeneration. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) contributes to immune tolerance by inhibiting T cell-mediated autoimmunity. Here, we show that a reduced expression of TIGIT in CD4+ T cells from patients with PM promotes these cells' differentiation into Th1 and Th17 cells, which could be rescued by TIGIT overexpression. Knockout of TIGIT enhances muscle inflam ...[more]

PMID: 40374622

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