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Overexpression of Initiator Methionine tRNA Suppresses Cancer Malignancy via Energy Depletion

ABSTRACT: Translation is an essential process for all living cell types, and translation dysregulation is a common feature in cancer cells that maintain the malignacy. tRNA-iMet is essential for initiation of translation, and tRNA-iMet was considered a cancer-promoting molecular factor, as elevated tRNA-iMet levels could enhance the vigorous translation and acceralate growth of cancers. Currently, the mainstream strategies of targeting therapies for cancer theatment are to target specific alterations of oncogenes or oncoproteins invoved in certain cancer pathways, however, the adquired resistance to these treatments seem to be inevitable. There is few research explored what happens if further elevate the expression of oncogenes, based on the philosophy saying ”No Extreme will Hold Long”. In this study, we exhibite that overexpression of tRNA-iMet could inhibite growth of multiple types of cancers via energy depletion. This stratege proposed by this study displays a potential and promising option of cancer treatmen for clinical translation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Gong Zhang

PROVIDER: PXD055419 | iProX | Wed Aug 28 00:00:00 BST 2024

REPOSITORIES: iProX

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