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Proteomic studies of mechanism of action of apigenin in stromal cells by five proteomic experiments

ABSTRACT: The present studies consist of five proteomic experiments: proteomic profiling treated by apigenin; DARTS coupled MS analysis to identify the potential directed proteins targets of apigenin; Identification of the potential directed protein targets of biotin-apigenin by pull-down coupled MS analysis; proteomic profiling of senescent cells upon treatment with MJ33; Identification of the proteins interacting with PRDX6 by Co-IP coupled MS analysis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yu Sun

PROVIDER: PXD055761 | iProX | Mon Jan 20 00:00:00 GMT 2025

REPOSITORIES: iProX

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Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age-Related Conditions in Mice.

Zhang Hongwei H Xu Qixia Q Jiang Zhirui Z Sun Rong R Wang Qun Q Liu Sanhong S Luan Xin X Campisi Judith J Kirkland James L JL Zhang Weidong W Sun Yu Y

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20250423 20

Cellular senescence is a cell fate triggered by stressful stimuli and displays a hypersecretory feature, the senescence-associated secretory phenotype (SASP). Senescent cell burden increases with aging and contributes to age-related organ dysfunction and multiple chronic disorders. In this study, a large scale screening of a natural product library for senotherapeutic candidates is performed. Apigenin, a dietary flavonoid previously reported with antioxidant and anti-inflammatory activities, exh ...[more]

PMID: 40265973

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