Dataset Information
Differential proteomic and phosphoproteomic analysis of Hnrnpk conditional knockout mouse testes
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Yongjie Xu
PROVIDER: PXD056125 | iProX | Sat Sep 14 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
Insights into the role of hnRNPK in spermatogenesis via the piRNA pathway.
Scientific reports 20250222 1
Deletion of hnRNPK in mouse spermatogonia leads to male sterility due to arrest permatogenesis, yet the underlying molecular mechanisms remain elusive. This study investigated the testicular proteome on postnatal day 28 (P28) to elucidate the infertility associated with Hnrnpk deficiency, identifying 791 proteins with altered expression: 256 were upregulated, and 535 were downregulated. Pathway enrichment analysis demonstrated that the downregulated proteins are primarily involved in spermatogen ...[more]
