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Metastatic serum secretome for discovering organ-specific metastasis of lung adenocarcinoma

ABSTRACT: The metastatic serum samples were collected from LUAD cohort, and were profiled to discover the metastatic serum secretome.

ORGANISM(S): Homo Sapiens

SUBMITTER: Caicun Zhou

PROVIDER: PXD056137 | iProX | Wed Sep 18 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX

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Multi-omics with dynamic network biomarker algorithm prefigures organ-specific metastasis of lung adenocarcinoma.

Zhang Xiaoshen X Xiao Kai K Wen Yaokai Y Wu Fengying F Gao Guanghui G Chen Luonan L Zhou Caicun C

Nature communications 20241114 1

Efficacious strategies for early detection of lung cancer metastasis are of significance for improving the survival of lung cancer patients. Here we show the marker genes and serum secretome foreshadowing the lung cancer site-specific metastasis through dynamic network biomarker (DNB) algorithm, utilizing two clinical cohorts of four major types of lung cancer distant metastases, with single-cell RNA sequencing (scRNA-seq) of primary lesions and liquid chromatography-mass spectrometry data of se ...[more]

PMID: 39543109

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