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Integrated Transcriptomic and Proteomic Analysis to Identify Genes and Molecular Mechanisms Regulating Deer Antler Growth and Ossification

ABSTRACT: Velvet antler is an organ composed of skin, nerves, blood vessels, cartilage and other tissues. Due to its ability to regenerate annually, it is used as a model for regeneration and medical research into cartilage related diseases. The study of the growth and development mechanisms of antlers has been the focus of many scholars. According to histological studies, antlers can be divided from distal to proximal into four tissue layers related to cartilage formation: reserve mesenchyme (RM), pre-cartilage (PC), transition zone (TZ), and cartilage area (CA). This study aims to identify key genes and pathways regulating antler growth and chondrogenesis by analyzing gene and protein expression levels in the four tissue layers (RM, PC, TZ, CA) of antlers.

ORGANISM(S): Elaphurus Davidianus

SUBMITTER: Pan Zhang

PROVIDER: PXD056140 | iProX | Wed Sep 18 00:00:00 BST 2024

REPOSITORIES: iProX

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Integrated Transcriptomic and Proteomic Analyses of Antler Growth and Ossification Mechanisms.

Liu Ruijia R Zhang Pan P Bai Jiade J Zhong Zhenyu Z Shan Yunfang Y Cheng Zhibin Z Zhang Qingxun Q Guo Qingyun Q Zhang Hao H Zhang Bo B

International journal of molecular sciences 20241209 23

Antlers are the sole mammalian organs capable of continuous regeneration. This distinctive feature has evolved into various biomedical models. Research on mechanisms of antler growth, development, and ossification provides valuable insights for limb regeneration, cartilage-related diseases, and cancer mechanisms. Here, ribonucleic acid sequencing (RNA-seq) and four-dimensional data-independent acquisition (4D DIA) technologies were employed to examine gene and protein expression differences amon ...[more]

PMID: 39684926

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