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LSDV012 interacts with IFIT1/5 coip data

ABSTRACT: LSDV012 interacts with IFIT1/5 Co-Immunoprecipitationdata

ORGANISM(S): Bos Taurus

SUBMITTER: Peng Chen

PROVIDER: PXD056306 | iProX | Thu Sep 26 00:00:00 BST 2024

REPOSITORIES: iProX

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A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability.

Xie Shijie S Fang Yongxiang Y Liao Zhiyi Z Cui Lianxin L Niu Kang K Ren Shuning S Zhu Junda J Wu Wenxue W Jing Zhizhong Z Peng Chen C

PLoS pathogens 20250317 3

Poxviruses are large DNA viruses with an arsenal of immune-modulatory genes, many of which remain uncharacterized. Proteins with ankyrin repeats are distinct features of poxviruses, although the biological functions of ankyrin proteins are not fully understood. Lumpy skin disease virus (LSDV) encodes five proteins with ankyrin repeats. Here, we reveal the role of LSDV012, an ankyrin protein, in conferring resistance to type I interferon (IFN) in cells. Deletion of LSDV012 from LSDV significantly ...[more]

PMID: 40096184

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