Integrated Proteogenomic Characterization of Localized Prostate Cancer Identifies Biological Insights and Subtype-Specific Therapeutic Strategies

ABSTRACT: We profiled the genome, transcriptome, proteome and phosphoproteome of 145 cases of localized prostate cancer (PCa) in Chinese patients and revealed three subtypes with distinct molecular features. We integrated multi-omic data to refine molecular subtyping of localized PCa, and identified NANS as a potential prognostic biomarker and therapeutic option for aggressive PCa.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zongren Wang  

PROVIDER: PXD056748 | iProX | Wed Oct 23 00:00:00 BST 2024

REPOSITORIES: iProX