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Chemically Engineered Antibodies for Autophagy-based Receptor Degradation.

ABSTRACT: Quantitative proteomic analysis raw data for the manuscript entitled “Chemically Engineered Antibodies for Autophagy-based Receptor Degradation”.

ORGANISM(S): Homo Sapiens

SUBMITTER: Hongchang Li

PROVIDER: PXD056766 | iProX | Sat Oct 12 00:00:00 BST 2024

REPOSITORIES: iProX

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Chemically engineered antibodies for autophagy-based receptor degradation.

Cheng Binghua B Li Meiqing M Zheng Jiwei J Liang Jiaming J Li Yanyan Y Liang Ruijing R Tian Hui H Zhou Zeyu Z Ding Li L Ren Jian J Shi Wenli W Zhou Wenjie W Hu Hailiang H Meng Long L Liu Ke K Cai Lintao L Shao Ximing X Fang Lijing L Li Hongchang H

Nature chemical biology 20250109 6

Cell surface receptor-targeted protein degraders hold promise for drug discovery. However, their application is restricted because of the complexity of creating bifunctional degraders and the reliance on specific lysosome-shuttling receptors or E3 ubiquitin ligases. To address these limitations, we developed an autophagy-based plasma membrane protein degradation platform, which we term AUTABs (autophagy-inducing antibodies). Through covalent conjugation with polyethylenimine (PEI), the engineere ...[more]

PMID: 39789191

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Chemically Engineered Antibodies for Autophagy-based Receptor Degradation

Project description:Chemically Engineered Antibodies for Autophagy-based Receptor Degradation

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