Proteomics

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Targeting WTX-P54nrb Phase Separation Sensitizes Chemotherapy in Gastric Cancer

ABSTRACT: To provide insights into any distinctions between the cellular functions of WTX-S and WTX-L, we defined their protein interaction networks by performing liquid chromatography–tandem MS of affinity-purified protein complexes.

ORGANISM(S): Homo Sapiens

SUBMITTER: Qingling Zhang  

PROVIDER: PXD057127 | iProX | Wed Oct 23 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX

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Disrupting Paraspeckle Stability by Targeting WTX-NONO Phase Separation Enhances Chemotherapy Efficacy in Gastric Cancer.

Xu Yangwei Y   Ye Zaisheng Z   Lin Zhihao Z   Qian Xuexia X   Li Yanyan Y   Sun Fei F   Chen Zetao Z   Zhao Zhangting Z   Bai Junping J   Du Meihang M   Li Yi-Chuan YC   Li Xuanqi X   Han Lijun L   Zhang Huanhu H   Hung Mien-Chie MC   An Liwei L   Zhang Qingling Q  

Cancer research 20260201 3

Nuclear paraspeckles play critical roles in orchestrating gene transcription to support tumor development and progression. Elucidating regulators of their dynamic compositions and formation could provide potential targets for treating cancer. In this study, we discovered that the short isoform of Wilms tumor gene on the X chromosome (WTX-S) specifically disrupted paraspeckle stability. WTX-S selectively interacted with and sequestered NONO (also as p54nrb) from paraspeckles. Mechanistically, int  ...[more]

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