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Systematic Proteomics Revealed The mechanism of How Long-term Tibetan Buddhist Meditation Enhanced Cardiovascular Protection

ABSTRACT: The difficulty to obtain data from whom uninterruptedly practice meditation over many years, and lacking of advanced analysis methods significantly hinder the comprehensive understanding of molecular mechanisms underlying meditation. This study aimed to address this issue.Accordingly, we recruited 86 advanced Tibetan Buddhists and 59 matched Tibetan controls in Tibet . Coupled with multiple data independent acquisition and parallel reaction morning spectrometry techniques, we systematically investigated the molecular basis of how meditation affect cardiovascular protection.

ORGANISM(S): Homo Sapiens

SUBMITTER: Donghong Cui

PROVIDER: PXD057418 | iProX | Thu Sep 27 00:00:00 BST 2018

REPOSITORIES: iProX

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The heart-brain axis: A proteomics study of meditation on the cardiovascular system of Tibetan Monks.

Xue Ting T Chiao Benjamin B Xu Tianjiao T Li Han H Shi Kai K Cheng Ying Y Shi Yuan Y Guo Xiaoli X Tong Shanbao S Guo Menglin M Chew Soo Hong SH Ebstein Richard P RP Cui Donghong D

EBioMedicine 20220513

<h4>Background</h4>There have been mixed reports on the beneficial effects of meditation in cardiovascular disease (CVD), which is widely considered the leading cause of death worldwide.<h4>Methods</h4>To clarify the role of meditation in modulating the heart-brain axis, we implemented an extreme phenotype strategy, i.e., Tibetan monks (BMI > 30) who practised 19.20 ± 7.82 years of meditation on average and their strictly matched non-meditative Tibetan controls. Hypothesis-free advanced proteomi ...[more]

PMID: 35576643

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