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Mass spectrometry of different lymph node metastasis states in papillary thyroid carcinoma

ABSTRACT: Most patients with papillary thyroid microcarcinoma (PTMC) have excellent prognoses with an indolent clinical courses. However, patients with lateral lymph node metastasis (LLNM) may experience higher locoregional recurrence rates and poorer prognoses. Therefore, it is crucial to establish an effective preoperative stratification strategy to reliably assess the risk of LLNM. PTMC samples were obtained from Peking Union Medical College Hospital. The data-independent acquisition mass spectrometry proteomics technique was used to identify protein profiles on PTMC tissues with and without LLNM.

ORGANISM(S): 智人

SUBMITTER: Ziwen Liu

PROVIDER: PXD057473 | iProX | Sun Nov 03 00:00:00 GMT 2024

REPOSITORIES: iProX

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Proteomic Analysis of Tissue Proteins Related to Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.

Zhang Qiyao Q Cao Zhen Z Wang Yuanyang Y Wu Hao H Zhang Zejian Z Liu Ziwen Z

Journal of proteome research 20241127 1

Patients with lateral lymph node metastasis (LLNM) may experience higher locoregional recurrence rates and poorer prognoses compared to those without LLNM, highlighting the need for effective preoperative stratification to reliably assess risk LLNM. In this study, we collected PTMC samples from Peking Union Medical College Hospital and employed data-independent acquisition mass spectrometry proteomics technique to identify protein profiles in PTMC tissues with and without LLNM. Pseudo temporal a ...[more]

PMID: 39600146

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