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Mechanism and Experimental Verification of Xiaoyao San in the Treatment of Nonalcoholic Fatty Liver Disease in Rats Using Transcriptomics and Proteomics Analysis

ABSTRACT: Mechanism and Experimental Verification of Xiaoyao San in the Treatment of Nonalcoholic Fatty Liver Disease in Rats Using Transcriptomics and Proteomics Analysis

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Shuanghu Wang

PROVIDER: PXD057729 | iProX | Mon Nov 11 00:00:00 GMT 2024

REPOSITORIES: iProX

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The effects and mechanisms of Xiaoyao San on nonalcoholic fatty liver disease rat based on transcriptomics and proteomics analysis.

Liu Yunxiao Y Wang Shuanghu S Younas Ayesha A Lv Jiaojian J Al Mamun Abdullah A Shao Chuxiao C

Scientific reports 20250326 1

Nonalcoholic Fatty Liver Disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes and is closely associated with metabolic disturbances such as obesity, dyslipidemia, and insulin resistance. Despite its increasing prevalence and potential progression to severe liver conditions, there is currently no approved pharmaceutical intervention for NAFLD. Traditional Chinese Medicine (TCM) formulations, such as Xiaoyao San (XYS), have shown therapeutic efficacy in treating NAFLD, b ...[more]

PMID: 40140444

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