Proteomic analysis of meninges from autoimmune encephalitis (mouse model)

ABSTRACT: We developed a B-cell-mediated mouse model of Anti-N-Methyl-D-aspartate receptor autoimmune encephalitis (AE) by immunization with a GluN1359–378 peptide. In our model, mice display a series of symptoms that recapitulate autoimmune encephalitis such as anxiety behaviour and spatial memory impairment (Wagnon et al, Brain 2020) . Proteomic analysis of AE meninges showed enrichment of differentially expressed proteins in biological processes associated with B cell activation and cytokine signalling pathways.

ORGANISM(S): Mus Musculus

SUBMITTER: Olivier Toutirais  

PROVIDER: PXD057817 | iProX | Tue Nov 12 00:00:00 GMT 2024

REPOSITORIES: iProX