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Zfp260 choreographs the early stage lineage commitment of skeletal stem cells

ABSTRACT: Zfp260 choreographs the early stage lineage commitment of skeletal stem cells

ORGANISM(S): Mus Musculus

SUBMITTER: Zuolin Wang

PROVIDER: PXD057880 | iProX | Thu Nov 14 00:00:00 GMT 2024

REPOSITORIES: iProX

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Zfp260 choreographs the early stage osteo-lineage commitment of skeletal stem cells.

Weng Yuteng Y Feng Yanhuizhi Y Li Zeyuan Z Xu Shuyu S Wu Di D Huang Jie J Wang Haicheng H Wang Zuolin Z

Nature communications 20241124 1

The initial fine-tuning processes are crucial for successful bone regeneration, as they guide skeletal stem cells through progenitor differentiation toward osteo- or chondrogenic fate. While fate determination processes are well-documented, the mechanisms preceding progenitor commitment remain poorly understood. Here, we identified a transcription factor, Zfp260, as pivotal for stem cell maturation into progenitors and directing osteogenic differentiation. Zfp260 is markedly up-regulated as cell ...[more]

PMID: 39582024

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