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DIA quantitative proteomics of CENPM knockdown SW-13 cells

ABSTRACT: The project aims to detect the differential expression of proteomics in normal SW-13 cells and CENPM knockdown SW-13 cells

ORGANISM(S): Homo Sapiens

SUBMITTER: Wenxia Su

PROVIDER: PXD058018 | iProX | Tue Nov 19 00:00:00 GMT 2024

REPOSITORIES: iProX

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Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1.

Zou Cunru C Zhang Yu Y Liu Chengyue C Li Yaxin Y Lin Congjie C Chen Hao H Hou Jiangping J Gao Guojun G Liu Zheng Z Yan Qiupeng Q Su Wenxia W

Clinical and translational medicine 20250101 1

<h4>Background</h4>Distant metastasis occurs in the majority of adrenocortical carcinoma (ACC), leading to an extremely poor prognosis. However, the key genes driving ACC metastasis remain unclear.<h4>Methods</h4>Weighted gene co-expression network analysis (WGCNA) and functional enrichment analysis were conducted to identify ACC metastasis-related genes. Data from RNA-seq and microarray were analyzed to reveal correlations of the CENPM gene with cancer, metastasis, and survival in ACC. Immunohi ...[more]

PMID: 39778025

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