Proteomics

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Serum proteomic analysis unravels novel biomarkers for amyotrophic lateral sclerosis


ABSTRACT: Amyotrophic lateral sclerosis (ALS), characterized by its insidious onset and progressive deterioration, poses a significant diagnostic challenge due to the lack of biomarkers in clinical practice. This study aims to unravel the serum biomarkers associated with ALS. We conducted a proteomic analysis of serum samples from a training group comprising 45 ALS patients and 45 healthy controls using magnetic bead-based immobilized metal ion affinity chromatography (MB-IMAC) and MALDI-TOF-MS technology. The differentially expressed peaks were screened using ClinProTools software and subsequently identified by LC-MS/MS.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chen Huang  

PROVIDER: PXD058115 | iProX | Wed Nov 20 00:00:00 GMT 2024

REPOSITORIES: iProX

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