Serum proteomic analysis unravels novel biomarkers for amyotrophic lateral sclerosis
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ABSTRACT: Amyotrophic lateral sclerosis (ALS), characterized by its insidious onset and progressive deterioration, poses a significant diagnostic challenge due to the lack of biomarkers in clinical practice. This study aims to unravel the serum biomarkers associated with ALS. We conducted a proteomic analysis of serum samples from a training group comprising 45 ALS patients and 45 healthy controls using magnetic bead-based immobilized metal ion affinity chromatography (MB-IMAC) and MALDI-TOF-MS technology. The differentially expressed peaks were screened using ClinProTools software and subsequently identified by LC-MS/MS.
ORGANISM(S): Homo Sapiens
SUBMITTER:
Chen Huang
PROVIDER: PXD058115 | iProX | Wed Nov 20 00:00:00 GMT 2024
REPOSITORIES: iProX
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