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The effects of enzalutamide on androgen-dependent and androgen-independent prostate cancer cells.

ABSTRACT: To investigate the mechanisms of drug resistance and castration resistance in prostate cancer, we performed proteomic sequencing on androgen-dependent prostate cancer cells (LNCaP) and androgen-independent cells (AI) treated with enzalutamide.

ORGANISM(S): Homo Sapiens

SUBMITTER: Guowei Shi

PROVIDER: PXD058261 | iProX | Tue Nov 26 00:00:00 GMT 2024

REPOSITORIES: iProX

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Elevated VRK1 levels after androgen deprivation therapy promote prostate cancer progression by upregulating YAP1 expression.

Meng Yibo Y Ge Jianchao J Zhou Cheng C Ma Hangbin H Chen Chenchen C Zhou Yinghao Y Hu Xuetao X Xu Yaozong Y Wang Xilong X Shi Guowei G Yu Wandong W Zhang Jun J

Journal of cancer research and clinical oncology 20250320 3

<h4>Purpose</h4>Vaccinia-related kinase 1 (VRK1) is a serine-threonine kinase involved in the proliferation and migration of various cancer cells. However, its role in prostate cancer (PCa), particularly in the development of therapeutic resistance, remains unclear.<h4>Methods</h4>We established an androgen-independent PCa cell line derived from LNCaP prostate cancer cells and conducted transcriptome and proteome sequencing together with bioinformatic analyses of large clinical sample databases ...[more]

PMID: 40111564

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