ATAD2 is a Potential Immunotherapy Target for Patients with Small Cell Lung Cancer Harboring HLA-A*0201
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Jie Wang
PROVIDER: PXD058303 | iProX | Tue Nov 26 00:00:00 GMT 2024
REPOSITORIES: iProX
Publications
ATAD2 is a potential immunotherapy target for patients with small cell lung cancer harboring HLA-A∗0201.
Yuan Li L Li Sini S Zhu Yixiang Y Yang Lin L Zhang Xue X Qu Yan Y Wang Zhijie Z Duan Jianchun J Zhong Jia J Tian Yanhua Y Liu Lihui L Sun Boyang B Fei Kailun K Liu Zheng Z Zhang Jian J He Yan Y Guo Yufeng Y He DanMing D Zhuang Wei W Zhang Jinsong J Ma Zixiao Z Bai Hua H Wang Jie J
EBioMedicine 20250113
<h4>Background</h4>Small cell lung cancer (SCLC) represents a highly aggressive neuroendocrine tumour with a dismal prognosis. Currently, the identification of a specific tumour antigen that can facilitate immune-based therapies for SCLC remains elusive.<h4>Methods</h4>We employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyse cancer/testis antigens (CTAs) in SCLC cell lines and human tumour specimens. Immunohistochemistry of clinical specimens was performed to compare prot ...[more]
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