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RACK7 Senses and Fine-Tunes Enhancer Activity

ABSTRACT: RACK7 senses enhancer activity changes and facilitates their activation

ORGANISM(S): Homo Sapiens

SUBMITTER: Hongjie Shen

PROVIDER: PXD058592 | iProX | Mon May 26 00:00:00 BST 2025

REPOSITORIES: iProX

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RACK7 senses and fine-tunes enhancer activity.

Dong Li L Zhang Daixuan D Cai Ying Y Zeng Min M Mu Mandi M Zhao Peng P Wang Jin J Cheng Siyi S Cai Qingqing Q Zhang Jian J Hu Yajun Y Zhang Lei L Tan Li L Wu Feizhen F Shi Yujiang Geno YG Xu Wenqi W Shen Hongjie H

iScience 20250709 8

Enhancers regulate dynamic gene expression in a spatiotemporal specific manner. A number of positive as well as negative regulators of enhancers have been reported so far. However, whether and how these regulators sense enhancer activity dynamics remains unclear. In this study, we show that a specific enhancer regulator, RACK7, swiftly re-distributes from repressed enhancers to activated enhancers in response to a plethora of acute stimulations. We further show that this process depends on trans ...[more]

PMID: 40734674

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