TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Bixiang Zhang
PROVIDER: PXD058674 | iProX | Fri Dec 06 00:00:00 GMT 2024
REPOSITORIES: iProX
Publications
TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway.
Dong Renshun R Wang Tianci T Dong Wei W Zhang Haoquan H Li Yani Y Tao Ran R Liu Qiumeng Q Liang Huifang H Chen Xiaoping X Zhang Bixiang B Zhang Xuewu X
Journal of hepatology 20250107 1
<h4>Background & aims</h4>Hepatocellular carcinoma (HCC) is an aggressive malignancy for which there are few effective treatment options. H3Q5ser, a serotonin-based histone modification mediated by transglutaminase 2 (TGM2), affects diverse biological processes, such as neurodevelopment. The role of TGM2-mediated H3Q5ser in HCC progression remains unclear. This study investigated the role of TGM2 in promoting HCC progression and evaluated its potential as a therapeutic target for HCC treatment.< ...[more]
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