Proteomics

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TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway

ABSTRACT: TGM2 IP-MS was performed in MHCC-97H cells to screen the interactors of TGM2. 5-PT pulldown-MS was perfromed in MHCC-97H cells to identify proteins modified by serotonylation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Bixiang Zhang  

PROVIDER: PXD058674 | iProX | Fri Dec 06 00:00:00 GMT 2024

REPOSITORIES: iProX

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TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway.

Dong Renshun R   Wang Tianci T   Dong Wei W   Zhang Haoquan H   Li Yani Y   Tao Ran R   Liu Qiumeng Q   Liang Huifang H   Chen Xiaoping X   Zhang Bixiang B   Zhang Xuewu X  

Journal of hepatology 20250107 1

<h4>Background & aims</h4>Hepatocellular carcinoma (HCC) is an aggressive malignancy for which there are few effective treatment options. H3Q5ser, a serotonin-based histone modification mediated by transglutaminase 2 (TGM2), affects diverse biological processes, such as neurodevelopment. The role of TGM2-mediated H3Q5ser in HCC progression remains unclear. This study investigated the role of TGM2 in promoting HCC progression and evaluated its potential as a therapeutic target for HCC treatment.<  ...[more]

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