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AKR1B10 inhibition enhances c-Myc stability by disrupting PP2A assembly

ABSTRACT: Immunoprecipitation-MS analysis to identify AKR1B10 interacting proteins.

ORGANISM(S): Homo Sapiens

SUBMITTER: Mei Song

PROVIDER: PXD058680 | iProX | Thu Jun 26 00:00:00 BST 2025

REPOSITORIES: iProX

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AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration.

Wu Xiaoxue X Huang Shaoqing S Gao Jialing J Huang Shuting S Chen Lulu L Zhao Ziyi Z Pu Ruihan R Ma Xiaojing X Liu Xianzhi X He Weiling W Song Mei M

Science advances 20250822 34

Metabolic enzymes, critical for cellular homeostasis, are frequently co-opted in a disease-specific manner to drive cancer progression. Here, we identify aldo-keto reductase family 1 member B10 (AKR1B10), down-regulated in gastrointestinal cancers, as a pivotal metastasis suppressor correlating with improved colorectal cancer (CRC) prognosis. Mechanistically, AKR1B10 activates protein phosphatase 2A (PP2A) by preventing redox-regulated nitration of its B56α subunit, preserving holoenzyme assembl ...[more]

PMID: 40845116

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