Proteomics

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AML cell line THP-1 shControl VS THP-1 shPSMB10

ABSTRACT: In the THP-1 cell line, knockdown of PSMB10 expression was performed using lentivirus, with a control group set up.

ORGANISM(S): Homo Sapiens

SUBMITTER: Lingbo Liu  

PROVIDER: PXD058714 | iProX | Tue Dec 10 00:00:00 GMT 2024

REPOSITORIES: iProX

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PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation manner.

Ma Xiao X   Li Yingnan Y   Wang Di D   Niu Jialan J   Li Qian Q   Chen Ying Y   Wang Mengyuan M   Wen Jin J   Liao Chenxi C   Wang Nan N   Zhang Xiaolan X   Chang Jiwei J   Yang Jiayi J   Li Lei L   Zou Jing J   Peng Danyue D   Liu Lingbo L  

Journal of experimental & clinical cancer research : CR 20250603 1

<h4>Background</h4>Drug resistance and relapse are still major challenges in acute myeloid leukemia (AML) because of the inability to effectively eradicate leukemia stem cells (LSCs). Senescence induction combined with immune killing may offer promising strategies for LSC eradication. However, whether and how drug-resistant LSCs retain stemness via senescence and immune regulation remains unknown.<h4>Methods</h4>The immunoproteasome subunit PSMB10 expression levels were analyzed by single-cell R  ...[more]

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