Proteomics

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Proteomics of epidural fibrosis after laminectomy


ABSTRACT: proteomics of epidural fibrosis after laminectomy (6 samples)

ORGANISM(S): Homo Sapiens

SUBMITTER: Mingshun Zhang  

PROVIDER: PXD059035 | iProX | Thu Dec 19 00:00:00 GMT 2024

REPOSITORIES: iProX

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Publications

Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte-myofibroblast transition in epidural fibrosis.

Hua Feng F   Sun Jinpeng J   Shi Mohan M   Mei Rui R   Song Zeyuan Z   Liu Jun J   Zhang Mingshun M  

NPJ Regenerative medicine 20241230 1


Epidural fibrosis post laminectomy is the leading cause of failed back surgery syndrome. Little is known about the role and mechanisms of adipose tissues in epidural fibrosis. Here, we found that obese patients were more likely to develop epidural fibrosis after spine surgery. Similarly, obesity led to more progressive epidural fibrosis in a mouse model of laminectomy. Adipocyte-myofibroblast transition (AMT) occurs in epidural scarring. Mechanistically, large extracellular vesicles (EVs) from M  ...[more]

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