Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Mingshun Zhang
PROVIDER: PXD059035 | iProX | Thu Dec 19 00:00:00 GMT 2024
REPOSITORIES: iProX
Hua Feng F Sun Jinpeng J Shi Mohan M Mei Rui R Song Zeyuan Z Liu Jun J Zhang Mingshun M
NPJ Regenerative medicine 20241230 1
Epidural fibrosis post laminectomy is the leading cause of failed back surgery syndrome. Little is known about the role and mechanisms of adipose tissues in epidural fibrosis. Here, we found that obese patients were more likely to develop epidural fibrosis after spine surgery. Similarly, obesity led to more progressive epidural fibrosis in a mouse model of laminectomy. Adipocyte-myofibroblast transition (AMT) occurs in epidural scarring. Mechanistically, large extracellular vesicles (EVs) from M ...[more]