Proteomics

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Identification of potential proteins bind to TGF-β receptor II in hepatic stellate cells


ABSTRACT: Activated hepatic stellate cells/myofibroblasts induced by TGF-β within the hepatic microenvironment are crucial determinants for cell growth and liver metastasis of colorectal cancer. Notably, TGF-β receptor II serves as the initiator of the received signal, and its membrane localization, internalization, degradation, and trafficking play a decisive role in determining the duration and intensity of TGF-β/SMAD signaling. This study aimed to identify the proteins that interact with TGF-β receptor II and clarify the underlying mechanisms of myofibroblastic activation of HSCs.

ORGANISM(S): Homo Sapiens

SUBMITTER: Liankang Sun  

PROVIDER: PXD059076 | iProX | Fri Dec 20 00:00:00 GMT 2024

REPOSITORIES: iProX

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