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Proteomic data of Fto-depleted skin and the control skin

ABSTRACT: Lentivirus expressing shRNA targeting Fto was intradermally injected into the back skin of wild-type C57BL/6j mice to locally knock down the expression of FTO in the skin. the proteome of control skin [shNC], Fto-depleted skin [shFto] were analysed by LC‒MS/MS.

ORGANISM(S): Mus Musculus

SUBMITTER: Ji Li

PROVIDER: PXD059134 | iProX | Fri Dec 20 00:00:00 GMT 2024

REPOSITORIES: iProX

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Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.

Wang Fan F Zhou Lei L Zhong Yun Y Cai Yisheng Y Meng Xin X Chen Mengting M Mao Rui R Xiao Xin X Yi Caitan C Guo Yi Y Xie Hongfu H Zhang Yiya Y Li Ji J

MedComm 20250709 7

N6-methyladenosine (m6A), as the most common RNA modification at the post-transcriptional level, plays a role in various pathophysiological processes. However, its underlying mechanism in skin aging remains enigmatic. Here, we identified that fat mass and obesity-associated protein (FTO) serves as a protective factor against skin aging. FTO expression is downregulated in aging skin tissues and senescent fibroblasts. Furthermore, the depletion or inhibition of FTO exacerbates dermal fibroblasts s ...[more]

PMID: 40636284

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