Proteomics

Dataset Information

0

Acetylated proteome data of young, old, FTO-knockdown and KAT8-overexpression human dermal fibroblasts

ABSTRACT: Acetylated proteome data of young human dermal fibroblasts (HDFs) [Young], old HDFs [Old], FTO-knockdown HDFs [shFTO], KAT8-overexpression HDFs [KAT8] and KAT8-overexpressed HDFs after FTO deprivation [shFTO_KAT8] were analysed by LC‒MS/MS.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ji Li  

PROVIDER: PXD059135 | iProX | Fri Dec 20 00:00:00 GMT 2024

REPOSITORIES: iProX

Json Xml
altmetric image

Publications

Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.

Wang Fan F   Zhou Lei L   Zhong Yun Y   Cai Yisheng Y   Meng Xin X   Chen Mengting M   Mao Rui R   Xiao Xin X   Yi Caitan C   Guo Yi Y   Xie Hongfu H   Zhang Yiya Y   Li Ji J  

MedComm 20250709 7

N6-methyladenosine (m6A), as the most common RNA modification at the post-transcriptional level, plays a role in various pathophysiological processes. However, its underlying mechanism in skin aging remains enigmatic. Here, we identified that fat mass and obesity-associated protein (FTO) serves as a protective factor against skin aging. FTO expression is downregulated in aging skin tissues and senescent fibroblasts. Furthermore, the depletion or inhibition of FTO exacerbates dermal fibroblasts s  ...[more]

Similar Datasets

Genomics mRNA expression of young, mid-old, and old fibroblasts
| PRJNA971965 | ENA
Transcriptomics mRNA expression of young, mid-old, and old fibroblasts
2023-05-19 | GSE232427 | GEO
Transcriptomics mRNA expression of mid-old fibroblasts co-cultured with young and mid-old fibroblasts
2023-05-19 | GSE232425 | GEO
Genomics mRNA expression of mid-old fibroblasts co-cultured with young and mid-old fibroblasts
| PRJNA971966 | ENA
Genomics miRNA profiling of Terc-/- mice plasma samples: in selenium deprivation or supplementation at young or old ages
2015-07-24 | GSE71256 | GEO
Proteomics TMT isobaric profiling of young versus old haematopoietic stem cells
2023-10-16 | MSV000093126 | MassIVE
Transcriptomics The comparison of MicroRNA profile of the dermis between young and old human
2016-02-05 | E-GEOD-72264 | biostudies-arrayexpress
Transcriptomics RNA sequencing of young and old lung ILC2 cells
2022-01-23 | GSE125584 | GEO
Genomics Real-time quantitative PCR analysis of primary human dermal fibroblasts: young, old and treated with GC4419
| PRJNA393436 | ENA
Genomics Gene expression in young and old pituitary
| PRJNA888784 | ENA