Dataset Information
Pan-analysis of Single Amino-acid Polymorphism
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Rong Zeng
PROVIDER: PXD059327 | iProX | Tue Dec 31 00:00:00 GMT 2024
REPOSITORIES: iProX
Publications
Uncovering dark mass in population proteomics: Pan-analysis of single amino acid polymorphism relevant to cognition and aging.
Cell genomics 20250130 2
Human proteome data across populations have been analyzed extensively to reveal protein quantitative associations with physiological or pathological states, while the single amino acid polymorphism (SAP) has been rarely investigated. In this work, we introduce a pan-SAP workflow that relies on pan-database searching independent of individual genome sequencing. Using ten cohorts comprising 2,004 individuals related to cognition disorder and aging, we quantify the SAP sites in key proteins, such a ...[more]
