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Structural Analysis of Rabies Virus Glycoprotein

ABSTRACT: N-glycosylation structure analysis of rabies virus

ORGANISM(S): Homo Sapiens

SUBMITTER: Jian Zhou

PROVIDER: PXD059482 | iProX | Mon Jan 06 00:00:00 GMT 2025

REPOSITORIES: iProX

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Changes in the dynamic characteristics of G-protein can alter the immune-protection efficacy of rabies virus vaccine.

Chen Chang-Xu C-x Wang Xi X Su Wen W Tian Yuan Y Gao Yu Y Liu Dong-Lan D-l Xiang Hong H Liu Bo-Chuan B-c Shi Jin-Li J-l Zhang Yang Y Shen Dong D He Wen-Zhi W-z Yang Li L Hong Chao C Wu Fan F Shi Lei-Tai L-t Cun Yi-Na Y-n Zhou Jian J

Journal of virology 20250221 3

The efficacy of the G-protein is influenced by N-linked glycosylation, which serves as the sole immunogen of the rabies virus vaccine. However, achieving satisfactory immune-protection efficacy remains challenging, owing to the heterogeneous glycosylation of G-proteins. Within molecular dynamics, examining the impact of N-glycan heterogeneity on the structural characteristics of G-proteins provides insights into the relationship between antigens and the efficacy of rabies virus vaccines. Glycosy ...[more]

PMID: 39982033

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