Proteomics

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Proteomics analysis of silencing of FGGY gene on colorectal cancer cells

ABSTRACT: Proteomics analysis was used to screen differentially expressed proteins after knockdown of FGGY in HCT116 cells

ORGANISM(S): Homo Sapiens

SUBMITTER: Aling Shen  

PROVIDER: PXD059574 | iProX | Wed Jan 08 00:00:00 GMT 2025

REPOSITORIES: iProX

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Downregulating FGGY carbohydrate kinase domain containing promotes cell senescence by activating the p53/p21 signaling pathway in colorectal cancer.

Liu Liya L   Wu Meizhu M   Chen Youqin Y   Cheng Ying Y   Liu Sijia S   Zhang Xinran X   Xie Qiurong Q   Cao Liujing L   Wei Lihui L   Fang Yi Y   Jafri Anjum A   Sferra Thomas J TJ   Shen Aling A   Li Li L  

International journal of molecular medicine 20250321 5

Carbohydrate kinases serve an oncogenic role in several types of cancer; however, the function of FGGY carbohydrate kinase domain containing (FGGY) in colorectal cancer (CRC) remains unknown. The present study investigated the function and possible molecular mechanisms of FGGY in CRC. The results showed that elevated levels of FGGY mRNA and protein were observed in CRC tissues, and a higher expression of FGGY was associated with advanced N stage and reduced overall survival time in patients with  ...[more]

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