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Proteomics of APOE3 and APOE4 BMDMs

ABSTRACT: The protein expression differences of APOE3 and APOE4 bone marrow-derived macrophages.

ORGANISM(S): Mus Musculus

SUBMITTER: Jun Yao

PROVIDER: PXD059706 | iProX | Fri Jan 10 00:00:00 GMT 2025

REPOSITORIES: iProX

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APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae.

Chen Junru J Chen Haibing H Wei Qinjun Q Lu Yajie Y Wang Tianming T Pang Xiuhong X Xing Guangqian G Chen Zhibin Z Cao Xin X Yao Jun J

Cell death discovery 20250421 1

The ApoE-ε4 gene is a well-established genetic risk factor for neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis, which are characterized by axonal demyelination in the central nervous system. Recent studies have implicated ApoE-ε4 in age-related hearing loss (ARHL), suggesting a potential role of APOE4 isoform in peripheral nervous system degeneration. However, the role of APOE4 in ARHL are still unclear. In this study, we explored the potential role of APOE4 in axo ...[more]

PMID: 40258814

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