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Physical and chemical niche of human growth plate for polarized bone development

ABSTRACT: The significantly enriched proteins in growth plate-epiphysis interface compared to growth plate and epiphysis and the significantly enriched proteins in growth plate-metaphysis interface compared to growth plate and metaphysis;

ORGANISM(S): Homo Sapiens

SUBMITTER: Hongwei Ouyang

PROVIDER: PXD059908 | iProX | Thu Jan 16 00:00:00 GMT 2025

REPOSITORIES: iProX

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Physical and chemical niche of human growth plate for polarized bone development.

Xie Chang C Li Wenyue W Yao Xudong X Wu Boxuan B Fang Jinghua J Mao Renwei R Yan Yiyang Y Meng Hongxu H Wu Yan Y Zhang Xianzhu X Li Rui R Zhang Jie J Duan Wangping W Dai Xuesong X Wang Xiaozhao X Ouyang Hongwei H

Nature communications 20250808 1

Growth plate (GP), a critical cartilaginous structure in amniotes, underpins longitudinal bone growth, yet the intricate mechanisms behind its polarized mineralization during evolution remain unclear. Herein, employing high-resolution analytical techniques, we reveal that the GP-epiphysis interface displays a sharp transition in tissue modulus, acting as a protective shell for the underlying GP, whereas the GP-metaphysis interface exhibits a gradual modulus increase, enabling efficient load redi ...[more]

PMID: 40781081

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