The analysis of spermidine-binding proteins
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Jun Ma
PROVIDER: PXD060003 | iProX | Tue Jan 21 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
Methionine metabolite spermidine inhibits tumor pyroptosis by enhancing MYO6-mediated endocytosis.
Wu Jiawei J Ding Cong C Zhang Chuqing C Xu Zhimin Z Deng Zhenji Z Wei Hanmiao H He Tingxiang T Long Liufen L Tang Linglong L Ma Jun J Liang Xiaoyu X
Nature communications 20250304 1
The connection between amino acid metabolism and pyroptosis remains elusive. Herein, we screen the effect of individual amino acid on pyroptosis and identify that methionine inhibits GSDME-mediated pyroptosis. Mechanistic analyses unveil that MYO6, a unique actin-based motor protein, bridges the GSDME N-terminus (GSDME-NT) and the endocytic adaptor AP2, mediating endolysosomal degradation of GSDME-NT. This degradation is increased by the methionine-derived metabolite spermidine noncanonically by ...[more]
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