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Proteomic data of paeoniflorin alleviating acute hypoxic lung injury

ABSTRACT: Paeoniflorin can alleviate acute hypoxic lung injury both in vivo and in vitro. The project includes proteomic data from mouse lung tissue and HPMEC cells, as well as proteomic data for peoniflorin target screening based on Lip-MS.

ORGANISM(S): Homo Sapiens Mus Musculus

SUBMITTER: Yue Gao

PROVIDER: PXD060005 | iProX | Tue Jan 21 00:00:00 GMT 2025

REPOSITORIES: iProX

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Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2-SGK1 signaling.

Wu Zhenhui Z Wang Yihao Y Wang Renjie R Gao Rong R Li Shubei S Tu Bodan B Yin Xiubing X Li Maoxing M Zhou Wei W Xu Huanhua H Wu Zhenfeng Z Ma Zengchun Z Tang Xianglin X Xiao Chengrong C Gao Yue Y

Acta pharmaceutica Sinica. B 20251220 3

Hypobaric hypoxia-induced lung injury can exacerbate the incidence of plateau pulmonary edema, but relevant pharmacologic measures are relatively limited. Here, we investigate the possible role of paeoniflorin (Pae) in hypobaric hypoxia-induced lung injury. Through <i>in vivo</i> and <i>in vitro</i> experiments, we observed that Pae significantly ameliorated hypobaric hypoxia-triggered oxidative stress, inflammatory response, mitochondrial dysfunction and ferroptosis. Using limited proteolysis-m ...[more]

PMID: 41909739

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