Urine complement analysis implies complement activation is involved in membranous nephropathy

ABSTRACT: Total 1,427 differentially expressed proteins were identified between the MN and HC groups. KEGG pathway analysis showed significant enrichment of these DEPs in the complement-activated pathway within the MN group. Additionally, a correlation was found between proteinuria and the levels of 27 urinary complement proteins. Notably, Collectin12 (collec12) and C1s were positively correlated with tubular atrophy/interstitial fibrosis (TIF) and monocyte infiltration. Furthermore, urine CD59 emerged as a predictor of clinical remission. Lower deposition of C5b-9 in renal tissue and higher expression of CD59 were detected in clinical remission group than non-remission group.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yong Zhang  

PROVIDER: PXD060494 | iProX | Sat Feb 01 00:00:00 GMT 2025

REPOSITORIES: iProX