Integrative analysis of Multi-omics data of FGFR inhibitor
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Yongheng Chen
PROVIDER: PXD060496 | iProX | Wed Feb 05 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
Integrative Multi-Omics Approaches Reveal Selectivity Profiles and Molecular Mechanisms of FIIN-2, a Covalent FGFR Inhibitor.
Fu Ying Y Zhu Dandan D Chen Xiaojuan X Qu Lingzhi L Guo Ming M Zhang Shuhong S Xu Guangyu G Chen Zhuchu Z Li Maoyu M Chen Yongheng Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20250220 14
Fibroblast growth factor receptor (FGFR) inhibitors are emerged as an important class of targeted therapies in oncology, targeting key pathways associated with tumor growth, angiogenesis, and resistance to conventional treatments. FIIN-2, the first irreversible covalent pan-FGFR inhibitor, has shown promise in overcoming resistance due to gatekeeper mutations; however, its selectivity and molecular mechanisms in tumors remain poorly understood. In this study, an FIIN-2 chemical probe is designed ...[more]
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