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Global profiling of the proteome and acetylome in mice with abdominal aortic aneurysms

ABSTRACT: Abdominal Aortic Aneurysm (AAA) is a fatal vascular disease characterized by abnormal expansion of the arterial wall and a high risk of rupture. Current treatments for AAA primarily rely on surgical intervention, while effective pharmacological therapies have yet to be developed. The major bottlenecks include an incomplete understanding of the disease mechanisms and a lack of efficient therapeutic targets.This study conducted a comprehensive proteome and acetylome analysis of mice models with abdominal aortic aneurysm to identify the key proteins, signaling pathways, and acetylation modification patterns involved in the progress of AAA.

ORGANISM(S): Mus Musculus

SUBMITTER: Juntao Yang

PROVIDER: PXD060895 | iProX | Mon Feb 17 00:00:00 GMT 2025

REPOSITORIES: iProX

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Global Profiling of the Proteome and Acetylome in Mice with Abdominal Aortic Aneurysms.

Zhang Luyao L Yang Bo B Ding Tao T Zhao Yaling Y Yang Yehong Y Tang Xiaoyue X Wu Yue Y Wang Qiaochu Q Zhang Zhiyi Z Shi Chunmei C Han Rong R Zhang Xutong X Liu Jiangfeng J Yang Juntao J

ACS omega 20251110 46

Abdominal aortic aneurysm (AAA) is a fatal vascular disease with a high rupture risk, and current treatments rely mainly on surgery. Pharmacological therapies are limited due to an incomplete understanding of disease mechanisms. This study aimed to identify potential targets for pharmacological intervention in AAA using a mouse model, focusing on proteomic and acetylomic alterations in aortic tissues. We successfully established a mouse AAA model and performed global proteomic and acetylomic ana ...[more]

PMID: 41322586

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