Mouse Testis IP-MS Analysis of TEX44 Interacting Proteins

ABSTRACT: Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine palmitoyltransferase 1B (CPT1B) to form a mitochondrial glue, anchoring adjacent mitochondria and facilitating the assembly of the sperm-specific mitochondrial sheath.

ORGANISM(S): Mus Musculus

SUBMITTER: Mingxi Liu  

PROVIDER: PXD060989 | iProX | Thu Feb 20 00:00:00 GMT 2025

REPOSITORIES: iProX