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PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation

ABSTRACT: MDA-MB-231 cells with expression of Flag-GPX4 were treated with IFNg. An immunoprecipitation assay was performed, and immunoprecipitates were subjected to masspec analysis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Daqian Xu

PROVIDER: PXD061373 | iProX | Sat Mar 01 00:00:00 GMT 2025

REPOSITORIES: iProX

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PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation.

Zheng Peixiang P Hu Zhiqiang Z Shen Yuli Y Gu Lina L Ouyang Yuan Y Duan Yuran Y Ji Guimei G Dong Bofei B Lin Yanni Y Wen Ting T Tian Qi Q Hou Yueru Y Zhou Qimin Q Sun Xue X Chen Xiaohan X Wang Katherine L KL Luo Shudi S Wu Shiqi S Sun Yuening Y Li Min M Xiao Liwei L Wu Qingang Q Meng Ying Y Liu Guijun G Wang Zheng Z Bai Xueli X Duan Shengzhong S Ding Yuan Y Bi Yanli Y Wang Yuhao Y Li Gaopeng G Liu Xiaoguang X Lu Zhimin Z Wu Xiaohong X Tang Zhiyuan Z Xu Daqian D

Nature chemical biology 20250425 9

Tumor cells adapt to the inflammatory tumor microenvironment (TME) and develop resistance to immunotherapy, with ferroptosis being a major form of tumor cell death. However, the mechanisms by which tumor cells coordinate TME stimuli and their unique metabolic traits to evade ferroptosis and develop resistance to immunotherapy remain unclear. Here we showed that interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II phosphorylates phosphoserine aminotransferase 1 (PSAT1) at ...[more]

PMID: 40281343

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