Dataset Information
IP-MS of NRVMs overexpressing Asb10
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus Norvegicus
SUBMITTER: 
Ke Lin
PROVIDER: PXD061568 | iProX | Fri Mar 07 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Cell death & disease 20250522 1
Cardiac hypertrophy is a pivotal risk factor for heart failure. Hypertension-induced pressure overload triggers left ventricular hypertrophy and leads to heart failure. Although the precise mechanisms remain incompletely elucidated, recent studies highlighted the role of ubiquitin-proteasome system in this process. As a heart tissue-enriched E3 ligase, the function of Asb10 in cardiac hypertrophy remains unknown. Here, we aimed to dissect the role of Asb10 in the pathogenesis of cardiac hypertro ...[more]
