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Mitochondria-derived-vesicles from mouse brown adipose tissue

ABSTRACT: Brown adipose tissue eject vesicles containing mitochondria proteins to maintain energy homeostasis. Here the quantitative proteomics identified the protein cargo of MDVs.

ORGANISM(S): Mus Musculus

SUBMITTER: Yaozu Xiang

PROVIDER: PXD061744 | iProX | Wed Mar 12 00:00:00 GMT 2025

REPOSITORIES: iProX

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Mitochondria-derived vesicles with bioenergetic units from brown adipose tissue attenuate cardiac remodeling post-myocardial infarction.

Shi Tingting T Chen Feng F Xu Yue Y Jiang Kai K Deng Ruhua R Yang Xingbo X Chen Yang Y Che Wenliang W Hwa John J Wang Dandan D Xiang Yaozu Y

Nature communications 20260521

Post-myocardial infarction remodeling is a major cause of heart failure, with contributions from multiple organs. Brown adipose tissue protects against cardiovascular disease, but the mediators of brown adipose tissue-heart crosstalk and their roles in cardiac remodeling remain elusive. Here, we show that mitochondria-derived vesicles from brown adipose tissue transfer to cardiac macrophages and attenuate pathological remodeling via anti-inflammatory effects. Vesicles containing mitochondrial me ...[more]

PMID: 42168207

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